Background: Proteins in the urine of women with preeclampsia (PE) bind Congo Red dye (urine congophilia). We sought to determine the diagnostic performance of a paper-based point-of-care test detecting urine congophilia for rapid triage and diagnosis of PE.
Methods: Prospective cohort study conducted in 346 consecutive pregnant women evaluated for PE in the Labour and Delivery triage unit at our institution. The Congo Red Dot (CRD) Paper Test (index test) was performed on fresh urine samples. The CRD Paper Test results were compared to an expert adjudicated diagnosis in each case. The accuracy of the CRD Paper Test was also compared to urine and serum analytes (placental growth factor and soluble fms-like tyrosine kinase-1) previously proposed as diagnostic aids for PE.
Findings: During the first triage visit, 32% (112/346) of women received a clinical diagnosis of PE. Yet, 63% (217/346) were admitted for in-patient diagnostic work-up or delivery. The CRD Paper Test was positive in 25% (86/346) of the cases. Adjudication confirmed PE in 28% (96/346) of all cases. The CRD Paper Test outperformed measured serum and urine markers (80·2% sensitivity, 89·2% specificity, 92·1% negative predictive value, 86·7% accuracy). The pre-test, positive and negative post-test probabilities were 27·7%, 74·0%, and 8·0%, respectively. Of women who were discharged undelivered, 38% (133/346) had at least one additional triage visit and the interval between the last negative and first positive CRD Paper Test was 12 (interquartile range, [5-34]) days.
Interpretation: The CRD Paper Test is a simple, non-invasive, "sample-in/answer-out" point-of-care clinical tool for rapid identification of PE.
Funding: Saving Lives at Birth Program and NICHD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537515 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2019.02.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mycobacterium tuberculosis (M.tb) infection can lead to various outcomes, including active tuberculosis or latent tuberculosis infection (LTBI). Household contacts of TB cases have a high risk of acquiring LTBI.
View Article and Find Full Text PDFElectrochemical reduction for chlorinated hydrocarbons contaminated groundwater remediation: Mechanisms, challenges, and perspectives.
Water Res
January 2025
State Key Laboratory of Geohazard Prevention and Geoenvironment Protection (Chengdu University of Technology), 1#, Dongsanlu, Erxianqiao, Chengdu 610059, Sichuan, PR China; State Environmental Protection Key Laboratory of Synergetic Control and Joint Remediation for Soil & Water Pollution (Chengdu University of Technology), 1#, Dongsanlu, Erxianqiao, Chengdu 610059, Sichuan, PR China. Electronic address:
Electrochemical reduction technology is a promising method for addressing the persistent contamination of groundwater by chlorinated hydrocarbons. Current research shows that electrochemical reductive dechlorination primarily relies on direct electron transfer (DET) and active hydrogen (H) mediated indirect electron transfer processes, thereby achieving efficient dechlorination and detoxification. This paper explores the influence of the molecular charge structure of chlorinated hydrocarbons, including chlorolefin, chloroalkanes, chlorinated aromatic hydrocarbons, and chloro-carboxylic acid, on reductive dechlorination from the perspective of molecular electrostatic potential and local electron affinity.
View Article and Find Full Text PDFAutomated mold defects classification in paintings: A comparison of machine learning and rule-based techniques.
PLoS One
January 2025
Faculty of Science and Engineering, School of Computer Science, University of Hull, Hull, United Kingdom.
Mold defects pose a significant risk to the preservation of valuable fine art paintings, typically arising from fungal growth in humid environments. This paper presents a novel approach for detecting and categorizing mold defects in fine art paintings. The technique leverages a feature extraction method called Derivative Level Thresholding to pinpoint suspicious regions within an image.
View Article and Find Full Text PDFKey barriers and decision supports in revitalizing heritage buildings from investors' perspective in China: A case study in Guangzhou, China.
PLoS One
January 2025
School of Architectural Engineering, Shenzhen Polytechnic University, Shenzhen, China.
In the decision-making process for investing in heritage buildings (HBs), various factors such as costs, interests, and tenancy terms influence investors decisions. Understanding the motivations of these investors can facilitate the involvement of social forces with diverse interests in adaptive reuse projects. This paper examines the primary barriers to revitalizing heritage buildings through adaptive reuse decision-making.
View Article and Find Full Text PDFVirtual reality perimetry compared to standard automated perimetry in adults with glaucoma: A systematic review.
PLoS One
January 2025
Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Purpose: The purpose of this systematic review was to consolidate and summarize available data comparing virtual reality perimetry (VRP) with standard automated perimetry (SAP) in adults with glaucoma. Understanding the utility and diagnostic performance of emerging VRP technology may expand access to visual field testing but requires evidence-based validation.
Methods: A systematic literature search was conducted in 3 databases (PubMed Central, Embase, and Cochrane Central Register of Controlled Trials) from the date of inception to 10/09/2024.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!