AI Article Synopsis
- The study explores Rap2a GTPase's role in the innate immune response and NF-κB activation triggered by LPS (lipopolysaccharide).
- It describes the development and optimization of molecular tools to analyze Rap2a's expression and activity in mammalian immune cells, particularly RAW264.7 macrophages and THP-1 monocytes.
- This research complements prior findings by the authors on Rap2a's involvement in immune function in macrophages in response to inflammation.
Article Abstract
We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531833 | PMC |
| http://dx.doi.org/10.1016/j.dib.2019.103965 | DOI Listing |
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