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Experimental evidence for use of (asarone) for cancer chemoprevention. | LitMetric

Cancer is one of the major non-communicable diseases posing substantial challenges in both developing and developed countries. The options available for treatment of different cancer are associated with various limitations, including severe toxicity, drug resistance, poor outcomes and a high risk of relapse. Hence, an increased attention and necessity for screening of various phytochemicals from natural sources for superior and safer alternative has been ongoing for several decades. In recent years, phytochemicals like galantamine, erwinaze, rivastigmine, resveratrol from natural sources have been found to be important therapeutic targets for the treatment of various diseases including cancer, neurodegeneration, diabetes, and cardiovascular effects. (Sweet flag), and/or its bioactive phytochemical alpha (α)-and beta (β)-asarone, is a well-known drug in the traditional system of medicine which possesses anti-tumor and chemo-preventive activities as evident from numerous pre-clinical studies both and . In this article, we critically review the current available scientific evidences of and/or asarone for cancer chemoprevention based on preclinical and models. In addition, we also have compiled and discussed the molecular targets of mechanism(s) involved in the anti-cancer activity of /asarone. Still, extensive studies are necessary using various animal models to understand the molecular mechanism behind the pharmacological activity of the bioactive phytochemicals derived from . It is strongly believed that the comprehensive evidence presented in this article could deliver a possible source for researchers to conduct future studies pertaining and/or its bioactive phytochemicals asarone for cancer chemoprevention.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513775PMC
http://dx.doi.org/10.1016/j.heliyon.2019.e01585DOI Listing

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