AI Article Synopsis
- Olive pollen is a major allergen due to global cultivation, leading researchers to analyze its proteome and allergenome using genomics and proteomics methods.
- A total of 1,907 proteins were identified, with 203 proteins linked to 47 allergen families, and a new allergen named Ole e 15 was discovered.
- Ole e 15 primarily affects children, showing strong IgE recognition and significant cross-reactivity with various plant, animal, and fungal sources.
Article Abstract
Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree ( L.) pollen proteome and define its complex allergenome. A total of 1907 proteins were identified by LC-MS/MS using predicted protein sequences from its genome. Most proteins (60%) were predicted to possess catalytic activity and be involved in metabolic processes. In total, 203 proteins belonging to 47 allergen families were found in olive pollen. A peptidyl-prolyl isomerase, cyclophilin, produced in , was found as a new olive pollen allergen (Ole e 15). Most Ole e 15-sensitized patients were children (63%) and showed strong IgE recognition to the allergen. Ole e 15 shared high sequence identity with other plant, animal, and fungal cyclophilins and presented high IgE cross-reactivity with pollen, plant food, and animal extracts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jproteome.9b00167 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of UV-B stress on olive (Olea europaea L.) pollen tubes: A study of callose plug deposition and male germ unit integrity.
Protoplasma
November 2024
Department of Life Sciences, University of Siena, Via Mattioli 4, 53100, Siena, Italy.
While UV-B radiation is beneficial to plant growth, it can also cause adverse effects. The pollen tube, a key component of plant reproduction with a tip growth mechanism, is an excellent cellular model for understanding how environmental stressors such as UV-B radiation affect plant cell growth. This research investigated the effect of UV-B on olive pollen both before and after germination.
View Article and Find Full Text PDFAllergic Rhinitis in Israel: A Multicenter Study of Allergic Rhinitis Across Three Climate Zones.
Isr Med Assoc J
November 2024
Allergy and Immunology Unit, Shaare Zedek Medical Center, Jerusalem, Israel, Faculty of Medicine, Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
Article Synopsis
- Allergic rhinitis (AR) affects 5% to 50% of the population worldwide, but specific studies on sensitization in Israeli patients have been limited.* -
- A study of 1,308 AR patients in Israel revealed an 86% overall positive skin prick test rate, with indoor allergens affecting 76% of participants; the most common allergens identified were mites, olive tree pollen, grass pollen, and cat dander.* -
- The findings can help allergists customize skin prick test panels and improve immunotherapy by focusing on the most prevalent aeroallergens in different climate zones.*
Enhanced pollen tube performance at high temperature contributes to thermotolerant fruit and seed production in tomato.
Curr Biol
November 2024
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 60 Olive Street, Providence, RI 02912, USA. Electronic address:
Rising temperature extremes during critical reproductive periods threaten the yield of major grain and fruit crops. Flowering plant reproduction depends on the ability of pollen grains to generate a pollen tube, which elongates through the pistil to deliver sperm cells to female gametes for double fertilization. We used tomato as a model fruit crop to determine how high temperature affects the pollen tube growth phase, taking advantage of cultivars noted for fruit production in exceptionally hot growing seasons.
View Article and Find Full Text PDFAgreement of Peru-Based Allergy Tests for Respiratory Allergens in Allergic Rhinitis Patients.
J Immunol Res
November 2024
SANNA el Golf Clinic, Lima, Peru.
Article Synopsis
- The study evaluated the agreement between three allergy testing methods—Peruvian Immunoblot, SPT (skin prick tests), and ALEX-2—in patients with allergic rhinitis in Arequipa, Peru.
- 35 patients participated, with findings indicating varying sensitization rates for allergens not covered by the Immunoblot panel.
- The results revealed stronger concordance between ALEX-2 and SPT compared to the agreement between Immunoblot and SPT.
Investigation of the diagnostic accuracy of basophil activation test for allergic phenotypes of rhinitis.
Allergy
November 2024
Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain.
Article Synopsis
- The study explores the potential of the Basophil Activation Test (BAT) as a replacement for the Nasal Allergen Challenge (NAC) in diagnosing different types of rhinitis due to allergies.
- It involved testing rhinitis patients with various allergens and analyzing the results of BAT alongside traditional skin prick tests to categorize patients into allergic and non-allergic phenotypes.
- Findings suggest BAT has a high ability to confirm allergic rhinitis, especially in patients with positive skin prick tests, while also identifying cases of allergy in patients who test negative on skin prick tests.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!