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http://dx.doi.org/10.1159/000495768 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
Dipartimento di Scienze della Vita, della Salute e delle Professioni Sanitarie, Università degli Studi "Link Campus University", Via del Casale di S. Pio V 44, I-00165 Rome, Italy.
, , and parasites are responsible for infectious diseases threatening millions of people worldwide. Despite more recent efforts devoted to the search for new antiprotozoal agents, efficacy, safety, and resistance issues still hinder the development of suited therapeutic options. The lack of robustly validated targets and the complexity of parasite's diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities.
View Article and Find Full Text PDFHeart Vessels
January 2025
Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
NPJ Antimicrob Resist
March 2024
Institute of Life Sciences, Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, Wales, UK.
The discoveries of penicillin and streptomycin were pivotal for infection control with the knowledge subsequently being used to enable the discovery of many other antibiotics currently used in clinical practice. These valuable compounds are generally derived from mesophilic soil microorganisms, predominantly Streptomyces species. Unfortunately, problems with the replication of results suggested that this discovery strategy was no longer viable, motivating a switch to combinatorial chemistry in conjunction with existing screening programmes to derive new antimicrobials.
View Article and Find Full Text PDFBr J Anaesth
January 2025
AIZH Statistics, Melbourne, Australia. Electronic address:
Br J Anaesth
January 2025
Department of Anaesthesiology and Intensive Therapy, Alfred Sokolowski Specialist Hospital in Walbrzych, Walbrzych, Poland.
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