Global Spine J
Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.
Published: May 2019
Study Design: Systematic review.
Objectives: To assess the efficacy of kyphoplasty in controlling pain and improving quality of life in oncologic patients with metastatic spinal disease and pathologic compression fractures of the spine.
Methods: A literature search through medical database was conducted (using PubMed, EMBASE, Cochrane, and LILACS) for randomized controlled trials comparing balloon kyphoplasty versus the traditional treatment for compression fractures of the spine due to metastatic disease. Two investigators independently assessed all titles and abstracts to select potential articles to be included. Inclusion criteria consisted of randomized controlled trials involving patients with pathologic compression fractures due to spinal metastasis or multiple myeloma treated with balloon kyphoplasty procedure as one of the study interventions, while the control group was any other treatment modality. The risk of bias in individual studies was assessed.
Results: Two studies, with a combined total of 181 patients, met inclusion criteria. Because of data heterogeneity, the meta-analysis was not possible, and individual analysis of studies was performed. There is moderate evidence that patients treated with balloon kyphoplasty displayed better scores for pain (Numeric Rating Scale), disability (Roland-Morris Disability Questionnaire), quality of life (Short Form-36 Health Survey), and functional status (Karnofsky Performance Status) compared with those undergoing the conventional treatment. Patients treated with kyphoplasty also have better recovery of vertebral height.
Conclusions: This study concluded that balloon kyphoplasty could be considered as an early treatment option for patients with symptomatic neoplastic spinal disease, although further randomized clinical trials should be performed for improvement of the quality of evidence.
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http://dx.doi.org/10.1177/2192568218768774 | DOI Listing |
J Orthop Sci
January 2025
Department of Orthopaedic Surgery, Nihon University Itabashi Hospital, 30-1 Oyaguchikamimati Itabashi-ku Tokyo 173-8610 Japan.
Background: Hounsfield unit values (HU) are known to correlate with dual-energy X-ray absorptiometry (DXA), and they are gaining attention as a new method for assessing Bone mineral density (BMD) that is not affected by the limitations of DXA, such as degeneration, scoliosis, and vascular calcification. The purpose of this study was to compare the efficacy of HU and DXA T-scores in predicting adjacent vertebral fractures (AVF) following balloon kyphoplasty (BKP) using the same computed tomography and DXA at one institution.
Methods: The study included 84 cases (20 males, 64 females, mean age 79.
Orthop Surg
January 2025
Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Objectives: Dual energy x-ray absorptiometry (DXA) provides incomplete information about bone strength. There are few data on the relationship between osteoporosis-related examinations and bone strength. The objective of the present study was to determine which osteoporosis-related examinations best predicted trabecular bone strength, and to enhance a formula for predicting bone strength on the basis of bone density examination.
View Article and Find Full Text PDFJBMR Plus
January 2025
Department of Orthopedics, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Preventing subsequent fractures after vertebral augmentation is a critical clinical concern. The purpose of this study was to compare the effect of romosozumab and bisphosphonate administration on the occurrence of subsequent vertebral fractures after balloon kyphoplasty (BKP) and to identify factors associated with the occurrence of subsequent vertebral fractures. The study compared 24 patients who underwent BKP and received romosozumab with 58 control patients who underwent BKP and received bisphosphonates, all within 2 months of acute osteoporotic vertebral fracture and showing unfavorable magnetic resonance imaging prognostic factors.
View Article and Find Full Text PDFSpine Surg Relat Res
November 2024
Department of Orthopaedic Surgery, University of Tsukuba, Tsukuba, Japan.
Introduction: Percutaneous vertebral augmentation techniques, such as balloon kyphoplasty (BKP) and vertebral body stenting (VBS), are commonly used for surgical intervention in osteoporotic vertebral fractures (OVFs). However, markedly unstable OVF cases require additional fixation procedures, prompting the exploration of combined percutaneous vertebral augmentation and posterior fixation. A novel surgical approach involving percutaneous vertebral augmentation with upward penetrating endplate screws (PES) and downward PES, complemented by a short fusion of one above one below, was developed.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
November 2024
University Centre for Orthopaedic, Trauma- and Plastic Surgery (OUPC), University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany; Centre for Translational Bone, Joint and Soft Tissue Research, Technical University Dresden, Dresden, Germany.
Background: The shoulder is the joint most often affected by dislocations. It is known that bony defects of the glenoid and/or humerus can lead to recurrent dislocations even after arthroscopic shoulder stabilization. To prevent recurrent instability, it appears reasonable to reduce fresh and larger Hill-Sachs lesions (off-track lesions).
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