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http://dx.doi.org/10.1155/2019/9154282 | DOI Listing |
There is growing interest to investigate classic psychedelics as potential therapeutics for mental illnesses. Previous studies have demonstrated that one dose of psilocybin leads to persisting neural and behavioral changes. The durability of psilocybin's effects suggests that there are likely alterations of gene expression at the transcriptional level.
View Article and Find Full Text PDFUnlabelled: Neurophysiology studies propose that predictive coding is implemented via alpha/beta (8-30 Hz) rhythms that prepare specific pathways to process predicted inputs. This leads to a state of relative inhibition, reducing feedforward gamma (40-90 Hz) rhythms and spiking to predictable inputs. We refer to this model as predictive routing.
View Article and Find Full Text PDFNat Ment Health
January 2025
Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerland.
Atypical face processing is commonly reported in autism. Its neural correlates have been explored extensively across single neuroimaging modalities within key regions of the face processing network, such as the fusiform gyrus (FFG). Nonetheless, it is poorly understood how variation in brain anatomy and function jointly impacts face processing and social functioning.
View Article and Find Full Text PDFAnim Cells Syst (Seoul)
January 2025
School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
βPix is a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases, which play important roles in dendritic spine morphogenesis by modulating actin cytoskeleton organization. The formation and plasticity of the dendritic spines are essential for normal brain function. Among the alternatively spliced βPix isoforms, βPix-b and βPix-d are expressed specifically in neurons.
View Article and Find Full Text PDFNeuronal pentraxin 2 (NP2) plays a significant role in synaptic plasticity, neuronal survival, and excitatory synapse regulation. Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, and neuropathies. This literature review extensively analyzes NP2's role in these conditions, thereby highlighting its contributions to synaptic dysfunction, neuroinflammation, and neurotoxic protein aggregation.
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