Applying categorization rules narrows attention toward the relevant features of a target and helps participants to ignore the irrelevant features of the target. This is called the shielding function of categorization rules. Here we explored the limitation of the shielding function in two task-switching experiments. In Experiment 1, we assigned each target a single digital numeral as an additional feature in addition to conventional bivalent features as in the previous task-switching experiments with bivalent tasks. In the first two stages of Experiment 1, half of the participants learned the numeral-response associations and the other half used an alternative numeral-categorization rule to infer the response. Without participants applying conventional task-switching rules, the switching costs disappeared. Moreover, when participants performed tasks by numeral-response associations the bivalent features interfered with response retrieval and caused response-congruency effects, whereas when participants applied the numeral-categorization rule, the bivalent features were shielded away and thereby the response-congruency effects disappeared. In the third stage, in which all participants applied task-switching rules by discriminating between bivalent features (i.e., filling and orientations), we found task-switching costs and response-congruency effects. In Experiment 2, new bivalent features produced stronger interference compared to Experiment 1. As a consequence, participants in both the association group and the numeral-categorization rule group showed significant response-congruency effects in the first two stages, where task-switching rules were not introduced. It follows that the shielding function of categorization rules has limits-strong interference from bivalent features can break down the shielding function. In addition, participants in the association group showed task-switching costs without being informed about the task-switching rules. We propose that strong proactive interference can produce task-switching costs even without the use of task-switching rules.
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http://dx.doi.org/10.3389/fpsyg.2019.01212 | DOI Listing |
Sci Rep
December 2024
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Transferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain. At therapeutically relevant concentrations, bivalent binding to TfR appears to reduce the transcytosis efficiency by receptor crosslinking. In this study, we aimed to improve BBB transcytosis of symmetric antibodies through minimizing their ability to cause TfR crosslinking.
View Article and Find Full Text PDFJ Med Chem
December 2024
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts (CAFs), represents a promising target for cancer diagnosis and therapy. Hypoxia is a common feature of solid tumors. A bivalent agent, DOTA-NI-FAPI-04 (), was developed by incorporating hypoxia-sensitive nitroimidazole (NI) into the FAP-targeting agent FAPI-04.
View Article and Find Full Text PDFJ Autoimmun
December 2024
Immunology Discovery Research, Lilly Research Laboratories, Lilly Biotechnology Center, San Diego, CA, USA. Electronic address:
PD-1 has emerged as a central inhibitory checkpoint receptor in maintaining immune homeostasis and as a target in cancer immunotherapies. However, targeting PD-1 for the treatment of autoimmune diseases has been more challenging. We recently showed in a phase 2a trial that PD-1 could be stimulated with the PD-1 agonist antibody peresolimab to treat rheumatoid arthritis.
View Article and Find Full Text PDFViruses
November 2024
Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, 38000 Grenoble, France.
The dynamic interplay between a multimeric phosphoprotein (P) and polymeric nucleoprotein (N) in complex with the viral RNA is at the heart of the functioning of the RNA-synthesizing machine of negative-sense RNA viruses of the order . P multimerization and N phosphorylation are often cited as key factors in regulating these interactions, but a detailed understanding of the molecular mechanisms is not yet available. Working with recombinant rabies virus (RABV) N and P proteins and using mainly surface plasmon resonance, we measured the binding interactions of full-length P dimers and of two monomeric fragments of either circular or linear N-RNA complexes, and we analyzed the equilibrium binding isotherms using different models.
View Article and Find Full Text PDFPlant Physiol Biochem
January 2025
School of Life Sciences, Guizhou Normal University, Guiyang, 550025, PR China. Electronic address:
Interspecific hybridization has been a crucial technique in improving genetic diversity and developing novel traits in cultivated plants. The apetalous Brassica juncea (AABB, 2n = 36) represents a valuable germplasm resource with highly desirable characteristics for breeding purposes. Nevertheless, apetalous germplasm resources in B.
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