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Red Blood Cell Distribution Width May Predict Drug-Induced Anemia and Prognosis in Patients Affected by Primary/Secondary Myelofibrosis Treated with Ruxolitinib.
Oncol Ther
January 2025
Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I-Sapienza University, Via Benevento 6, 00161, Rome, Italy.
Introduction: Myelofibrosis (MF) is often characterized by a multifactorial anemia determined, in part, by bone marrow (BM) fibrosis, extramedullary erythropoiesis and splenomegaly. Ruxolitinib (RUX) is the first-in-class janus kinase 2 (JAK2) inhibitor approved for treatment of MF, proved to reduce spleen volume and decrease symptom burden. The red cell distribution width (RDW) is the measure of erythrocyte volume variability (anisocytosis).
View Article and Find Full Text PDFThe long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure.
Biomark Med
October 2024
2ND Department of Internal Medicine, Medical Faculty of Charles University & University Hospital, Pilsen, Czech Republic.
Article Synopsis
- * Patients with RDW in the highest range had approximately double the risk of dying within five years compared to those with the lowest RDW.
- * This association remained strong even after accounting for other risk factors and excluding patients who died within the first year, indicating that high RDW is an independent predictor of poor outcomes in heart failure patients.
B-cell small lymphocytic lymphoma in a free-ranging South American fur seal (Arctocephalus australis).
Dis Aquat Organ
October 2023
Programa de Pós-graduação em Ciências Veterinárias (PPGCV) Faculdade de Veterinária, (FAVET), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 91540-000, Brazil.
Lymphomas are malignant neoplasms of the hematopoietic system arising from lymphocytes with highly variable biologic behavior. B-cell small lymphocytic lymphoma (B-SLL) is a non-Hodgkin lymphoma infrequently described in domestic and wild animals. The present study describes a case of B-SLL in a free-ranging adult male Arctocephalus australis in Brazil.
View Article and Find Full Text PDFIron Deficiency Anemia: An Updated Review.
Curr Pediatr Rev
January 2024
Department of Pathology, Hong Kong Children's Hospital, Hong Kong.
Background: Worldwide, iron deficiency anemia is the most prevalent nutritional deficiency disorder and the leading cause of anemia in children, especially in developing countries. When present in early childhood, especially if severe and prolonged, iron deficiency anemia can result in neurodevelopmental and cognitive deficits, which may not always be fully reversible even following the correction of iron deficiency anemia.
Objective: This article aimed to familiarize physicians with the clinical manifestations, diagnosis, evaluation, prevention, and management of children with iron deficiency anemia.
Extreme thrombocytosis with severe anemia and infection in a Sudanese patient: A case report.
Ann Med Surg (Lond)
December 2022
Sudan Medical Specialization Board, Sudan.
Introduction: Secondary thrombocytosis, also known as reactive thrombocytosis, is defined as an abnormal increase in platelet count as a result of another underlying medical or surgical condition. Once the medical cause of reactive thrombocytosis was determined, it could be treated. In this case, supportive treatment with no iron supplements for anemia and infection improved the case condition rapidly.
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