AI Article Synopsis
- Loss of OCRL leads to an increase in PtdIns(4,5)P levels on cell membranes, resulting in Lowe syndrome.
- Mondin et al. (2019) find that PTEN and PLCXD work together to reduce the accumulation of PtdIns(4,5)P in endosomes.
- This collaboration presents a potential compensatory mechanism that may offer insights into treatment strategies for conditions like Lowe syndrome.
Article Abstract
Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P accumulation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605809 | PMC |
| http://dx.doi.org/10.1083/jcb.201906022 | DOI Listing |
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