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Background: Renal atrophy may reflect an end organ consequence of chronic vascular disease. Renal volume loss may therefore provide a window into brain aging and Alzheimer disease risk.
Method: We obtained whole-body 1.
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Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Insulin resistance (IR) is associated with abnormal tau-phosphorylation and IR markers in AD brain co-localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insulin (INI) administration using specialized intranasal devices that deliver insulin to the brain. Our recent INI vs.
View Article and Find Full Text PDFBackground: Sarcopenia has been linked to brain atrophy and there is lack of information on specific muscle groups that may contribute to this link. The psoas muscles are sensitive to sarcopenia and thus may sensitively relate to brain aging and Alzheimer disease risk.
Method: This study utilized 7,149 healthy individuals across four sites (Mean age 53.
Background: Comparative information on how whole-body organs are linked with age and the brain is lacking.
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Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Background: Physical exercise improves clinical state of patients with Parkinson's disease (PD), and evidence from experimental models suggests it has a potential to slow down the disease progression. Improved glucose metabolism as well as exerkines, bioactive molecules released into circulation with each exercise bout, contribute to the synchronized exercise-induced adaptive response at a systemic level. Our aim was to assess effects of exercise on clinical state and molecular changes in cerebrospinal fluid (CSF) and blood of patients with PD.
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