Pharmacokinetic studies showed that endobronchial administration of benzylpenicillin and gentamicin to patients with acute and chronic pneumonia unlike intramuscular administration provided the antibiotic concentrations in bronchial secretions effective against middle sensitive and moderately resistant strains of microorganisms within 1-5 hours. Such concentrations maintained at the levels sufficient for inhibiting sensitive microflora growth for 24-36 hours with the use of benzylpenicillin and for 6 days with the use of gentamicin. This also lowered the risk of toxic complications.
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