Ceramic-on-ceramic bearings in total hip replacement have shown the potential to provide low wear solutions in hip replacement. Assessing the tribological performance of these materials is important to predict their long-term performance in patients. In this study, a methodology was devised to assess the tribological in vitro behaviour of composite ceramics under combined adverse edge loading conditions and accelerated ageing. Two commercial ceramic composites were considered, namely Alumina-Toughened Zirconia (ATZ, ceramys) and Zirconia-Toughened Alumina (ZTA, symarec). The bearing couples were studied using the Leeds Mark II hip joint simulator for a total of eight million cycles, the first two million under normal gait (no edge loading) and the following six million cycles with the addition of edge loading conditions driven by medial-lateral separation. The bearing couples underwent hydrothermal ageing using an accelerated protocol in autoclave every million cycles. The influence of edge loading combined with ageing was significant for ATZ bearings, resulting in a slower overall ageing kinetics over the wear stripe than on the control heads. During the autoclave ageing steps, the monoclinic fraction increased more over the wear stripe area than over the unworn area. Both results thus indicated that the monoclinic phase was removed during shocks induced by edge loading. The wear performance of the two materials were similar exhibiting relatively low wear rates and low level of microstructural damage for these clinically relevant adverse conditions.
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http://dx.doi.org/10.1016/j.jmbbm.2019.05.011 | DOI Listing |
Proc Natl Acad Sci U S A
February 2025
École polytechnique fédérale de Lausanne, School of Engineering, Institute of Mechanical Engineering, Unsteady Flow Diagnostics Laboratory, Lausanne 1015, Switzerland.
Airborne insects generate a leading edge vortex when they flap their wings. This coherent vortex is a low-pressure region that enhances the lift of flapping wings compared to fixed wings. Insect wings are thin membranes strengthened by a system of veins that does not allow large wing deformations.
View Article and Find Full Text PDFAnal Chem
January 2025
MOE Key Laboratory of Geriatric Nutrition and Health, Department of Bioengineering, Beijing Technology and Business University, Beijing 100048, China.
Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject of broad interest. Here, we propose a novel single-particle method for multiplexed miRNA detection using self-directed hydrogel microspheres, which feature supersegmented compartments for loading analyte probes and an air-encapsulated region that grants the microsphere a unique preferred posture in aqueous solutions. By exploiting microfluidic technology, we can widely adjust the size of the microspheres and the number of compartments can be widely adjusted.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa 13110, Jordan.
: The demand for a safe compound for hyperpigmentation is continuously increasing. Bioactive compounds such as thymoquinone (TQ) and ascorbic acid (AA) induce inhibition of melanogenesis with a high safety profile. The aim of this study was to design and evaluate spanlastics gel loaded with bioactive agents, TQ and AA, for the management of hyperpigmentation.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Airworthiness Division, Air Force Institute of Technology, 01-494 Warsaw, Poland.
The range of sensor technologies for structural health monitoring (SHM) systems is expanding as the need for ongoing structural monitoring increases. In such a case, damage to the monitored structure elements is detected using an integrated network of sensors operating in real-time or periodically in frequent time stamps. This paper briefly introduces a new type of sensor, called a Customized Crack Propagation Sensor (CCPS), which is an alternative for crack gauges, but with enhanced functional features and customizability.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Department of Civil Engineering, Myongji College, Seoul 03656, Republic of Korea.
Conventional approaches for the structural health monitoring of infrastructures often rely on physical sensors or targets attached to structural members, which require considerable preparation, maintenance, and operational effort, including continuous on-site adjustments. This paper presents an image-driven hybrid structural analysis technique that combines digital image processing (DIP) and regression analysis with a continuum point cloud method (CPCM) built on a particle-based strong formulation. Polynomial regressions capture the boundary shape change due to the structural loading and precisely identify the edge and corner coordinates of the deformed structure.
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