Fatty Acids Corrupt Neutrophils in Cancer.

Cancer Cell

Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

Published: June 2019

Understanding how tumors escape from immune attack may offer novel therapeutic opportunities. Veglia et al. (2019) demonstrate in Nature that fatty acid transport protein 2 (FATP2) endows neutrophils with immunosuppressive capabilities that promote cancer growth. This receptor can be targeted to unleash anti-tumor immunity and to potentiate immune checkpoint blockade.

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Source
http://dx.doi.org/10.1016/j.ccell.2019.05.007DOI Listing

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