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Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology.
Cell Rep
August 2024
Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
Article Synopsis
- * Contrary to the hypothesis, neurons without tangles died over three times more frequently than those with tangles, indicating that the presence of tangles may actually reduce neuronal death risk.
- * Changes in neuron structure were found to be better indicators of imminent death than the presence of tangles, suggesting new methods for identifying dying neurons in Alzheimer's.
Surgery or endovascular therapy for patients with chronic limb-threatening ischemia requiring infrapopliteal interventions.
J Vasc Surg
November 2024
Heart and Vascular Center, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Article Synopsis
- Two studies, BEST-CLI and BASIL-2, looked at different surgeries for patients with serious leg circulation problems and found mixed results.
- The analysis focused on patients from BEST-CLI who had severe leg issues and underwent either open bypass surgery or a less invasive method.
- Results showed that the surgical group had fewer major limb problems and needed fewer follow-up surgeries compared to the endovascular group, but death rates were similar for both groups.
Methods, design, and initial results of an angiographic core lab from VOYAGER-PAD.
Vasc Med
April 2024
Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.
Anatomy is critical in risk stratification and therapeutic decision making in coronary disease. The relationship between anatomy and outcomes is not well described in PAD. We sought to develop an angiographic core lab within the VOYAGER-PAD trial.
View Article and Find Full Text PDFRationale and Design of VOYAGER: Long-term Outcomes of Faricimab and Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Clinical Practice.
Ophthalmol Sci
December 2023
F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaining novel insight into the intersection of treatment regimens, decisions, anatomic outcomes, and vision.
Design: Primary data collection, noninterventional, prospective, multinational, multicenter clinical practice study.
Region-Dependent Mechanical Properties of Human Brain Tissue Under Large Deformations Using Inverse Finite Element Modeling.
Ann Biomed Eng
March 2024
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace MC 8904, 1210 Amsterdam Avenue, New York, NY, 10027, USA.
This study aims to facilitate intracranial simulation of traumatic events by determining the mechanical properties of different anatomical structures of the brain. Our experimental indentation paradigm used fresh, post-operative human tissue, which is highly advantageous in determining mechanical properties without being affected by postmortem time. This study employed an inverse finite element approach coupled with experimental indentation data to characterize mechanical properties of the human hippocampus (CA1, CA3, dentate gyrus), cortex white matter, and cortex grey matter.
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