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Dementia Care Practice.
Alzheimers Dement
December 2024
University of Massachusetts Amherst, Amherst, MA, USA.
Community-based organizations (CBOs) are an essential part of dementia service delivery to people living with dementia (PLWD) and family caregivers (CG) impacted by Alzheimer's and other dementias, however use of CBO services particularly by PLWD is limited. Referral of PLWD to CBOs by health systems (HS) and health care providers (HCPs) is a common way that PLWD come to use CBO services, but integration between CBOs and HS/HCPs is inconsistent. For example, referrals to CBOs might come from HS/HCPs or from other CBOs, these referrers might provide referrals for a single program or for multiple different programs, and the referrers might be physicians, social workers, case managers, or other clinicians.
View Article and Find Full Text PDFExceptionally large fluctuations in orientational order: The lessons of large-deviation theory for liquid crystalline systems.
J Chem Phys
January 2025
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
How condensed-matter simulations depend on the number of molecules being simulated (N) is sometimes itself a valuable piece of information. Liquid crystals provide a case in point. Light scattering and 2d-IR experiments on isotropic-phase samples display increasingly large orientational fluctuations ("pseudo-nematic domains") as the samples approach their nematic phase.
View Article and Find Full Text PDFSingle-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope's Clinical Trial Teams.
J Clin Med
December 2024
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Tumor heterogeneity is a significant factor influencing cancer treatment effectiveness and can arise from genetic, epigenetic, and phenotypic variations among cancer cells. Understanding how tumor heterogeneity impacts tumor evolution and therapy response can lead to more effective treatments and improved patient outcomes. Traditional bulk genomic approaches fail to provide insights into cellular-level events, whereas single-cell RNA sequencing (scRNA-seq) offers transcriptomic analysis at the individual cell level, advancing our understanding of tumor growth, progression, and drug response.
View Article and Find Full Text PDFEvolutionary mismatch in emotional support during childbirth: Lessons from the COVID-19 pandemic.
Evol Med Public Health
December 2024
Department of Anthropology, Washington University in St. Louis, St. Louis, MO, USA.
Background And Objectives: Selective pressures on human childbirth have led to the evolution of cooperative birth practices, with birth attendants playing a crucial role in providing emotional support during labor.
Methodology: We leveraged COVID-19-related healthcare disruptions to investigate the impact of the evolutionary mismatch in the availability of emotional support persons on perceived birth stress among a US-based convenience sample ( = 1082).
Results: Individuals who stated during pregnancy that they desired support from their partner or a doula but who did not receive this support had significantly higher perceived childbirth stress ( = 12.
Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy.
Angew Chem Int Ed Engl
January 2025
University of Chicago Division of the Physical Sciences, chemistry, UNITED STATES OF AMERICA.
Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers by leveraging the immune system to combat malignancies. However, its efficacy is limited by the immunosuppressive tumor microenvironment and other regulatory mechanisms of the immune system. Innate immune modulators (IIMs) provide potent immune activation to complement adaptive immune responses and help overcome resistance to ICB.
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