Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Insulin and myometrial contractility; Are there any links? A narrative review.
Reprod Biol
January 2025
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Contrary to the evidence supporting the role for insulin in stimulating uterine contraction, only a limited number of studies have highlighted the inhibitory effect of insulin on myometrial contractions in human and rodent. A hypothetical narrative review of the current literature was conducted, revealing the current literature and shows the potential inhibitory effects of insulin on myometrial contractility. These inhibitory mechanisms include activation of adenylyl cyclase signaling pathways, an increase in cAMP production, a decrease in Ca influx and cytosolic Ca, hyperpolarization of the cell membrane, and stimulation of NO synthesis.
View Article and Find Full Text PDFThe biosynthesis of cyclic 3',5'-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs). Up to now the two hexahelical transmembrane domains of mACs were considered to fix the enzyme to membranes. Here, we show that the transmembrane domains serve in addition as signal receptors and transmitters of lipid signals that control Gsα-stimulated mAC activities.
View Article and Find Full Text PDFCell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission.
PLoS Genet
November 2024
Department of Biological Sciences, Butler University, Indianapolis, Indiana, United States of America.
Modulation of neurotransmission is key for organismal responses to varying physiological contexts such as during infection, injury, or other stresses, as well as in learning and memory and for sensory adaptation. Roles for cell autonomous neuromodulatory mechanisms in these processes have been well described. The importance of cell non-autonomous pathways for inter-tissue signaling, such as gut-to-brain or glia-to-neuron, has emerged more recently, but the cellular mechanisms mediating such regulation remain comparatively unexplored.
View Article and Find Full Text PDFJinwu Jiangu Capsule alleviates rheumatoid arthritis symptoms by regulating the ADCY10 and cAMP/RANKL pathways.
J Ethnopharmacol
February 2025
Department of Rheumatology Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, 550001, China; Department of Liupanshui Hospital of Traditional Chinese Medicine, Liupanshui, Guizhou Province, 553000, China. Electronic address:
Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects joints and damages other tissues, including the heart, kidneys, lungs, digestive system, eyes, skin and nervous system. Jinwu Jiangu Capsule (JWJG) is effective in tonifying kidneys, activating blood circulation, and dispelling wind and dampness. Meanwhile, it produces favorable clinical results in relieving joint pain and reducing inflammation.
View Article and Find Full Text PDFIntracellular cAMP signaling-induced Ca influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts.
Pflugers Arch
November 2024
Department of Physiology, Tokyo Dental College, Tokyo, 101-0061, Japan.
In odontoblasts, intracellular Ca signaling plays key roles in reactionary dentin formation and generation of dentinal pain. Odontoblasts also express several G protein-coupled receptors that promote production of cyclic AMP (cAMP). However, the crosstalk between intracellular cAMP and Ca signaling, as well as the role of cAMP in the cellular functions of odontoblasts, remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!