Pathogenic strains cause a wide range of extra intestinal infections including urinary tract infection in humans and colibacillosis in poultry. They are classified into uropathogenic (UPEC) and avian pathogenic (APEC) with genetic similarities and variations. Their pathogenicity is related to the virulence-encoding genes like , , , and with zoonotic potentials. One hundred isolated from patients with urinary tract infection and 100 from chickens with colibacillosis were evaluated for the presence of the most common virulence-encoding genes including and by multiplex polymerase chain reaction. While the frequency of and encoding genes in APEC isolates were respectively 0.00%, 67.00%, 63.00%, 89.00% and 89.00%, the frequency of these encoding genes in UPEC isolates were 18.00%, 40.00%, 40.00%, 74.00% and 48.00%, respectively. Except for , the frequencies of other encoding genes in APEC were more than those in UPEC isolates. The as the most common UPEC encoding gene and as the most common APEC encoding gene were the most prevalent virulence factors in the examined isolates. Finding out the distribution of virulence-associated genes could be helpful to identify similarities and differences between APEC and UPEC isolates in order to provide more substantial evidence of their common virulence traits and potential zoonotic threats.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522195 | PMC |
| http://dx.doi.org/10.30466/vrf.2019.34307 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Public health concern of antimicrobial resistance and virulence determinants in E. coli isolates from oysters in Egypt.
Sci Rep
November 2024
Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, PO Box 12211, Giza, Egypt.
The emergence of critical-priority E. coli, carrying a wide array of resistance and virulence factors through food sources, poses a significant challenge to public health. This study aimed to investigate the potential role of oysters sold in Egypt as a source for E.
View Article and Find Full Text PDFExpression of the locus of enterocyte effacement genes during the invasion process of the atypical enteropathogenic 1711-4 strain of serotype O51:H40.
Microbiol Spectr
October 2024
Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Article Synopsis
- - Atypical enteropathogenic (aEPEC) is a big cause of diarrhea in poorer countries, and one specific strain called aEPEC 1711-4 can invade gut cells and even spread to other parts of the body in tests with rats.
- - Scientists studied how this strain interacts with cells in the intestines and found that it has special genes that help it stick and invade, but they still don’t totally understand how these processes work.
- - The research shows that although the strain can move into cells and stay there, more work is needed to figure out exactly how it does this and what makes it different from other bacteria.
Molecular Detection of Virulence-Associated Markers in and Isolates From Water, Cattle, and Chicken Faecal Samples From Kajiado County, Kenya.
Biomed Res Int
August 2024
Department of Public Health Pharmacology and Toxicology Faculty of Veterinary Medicine University of Nairobi, P.O. Box 29053-00625, Kangemi, Nairobi, Kenya.
is a zoonotic foodborne pathogen that is often linked with gastroenteritis and other extraintestinal infections in humans. This study is aimed at determining the genetic determinants of virulence-encoding genes responsible for flagellin motility protein A (), adhesion to fibronectin F (), invasion antigen B () and cytolethal distending toxin (cdt) A () in species. A total of 29 isolates (16 from cattle, 9 from chicken, and 4 from water samples) and 74 isolates (38 from cattle, 30 from chicken, and 6 from water samples) described in an earlier study in Kajiado County, Kenya, were examined for the occurrence of virulence-associated genes using polymerase chain reaction (PCR) and amplicon sequencing.
View Article and Find Full Text PDFAnti-virulence potential of iclaprim, a novel folic acid synthesis inhibitor, against Staphylococcus aureus.
Appl Microbiol Biotechnol
August 2024
Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd., Shanghai, 200071, China.
Infections caused by Staphylococcus aureus pose a significant global public problem. Therefore, new antibiotics and therapeutic strategies are needed to combat this pathogen. This investigation delves into the effects of iclaprim, a newly discovered inhibitor of folic acid synthesis, on S.
View Article and Find Full Text PDFUnravelling the genomic characteristics of a Klebsiella quasipneumoniae clinical isolate carrying bla.
J Glob Antimicrob Resist
September 2024
Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo SP, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo SP, Brazil.
Article Synopsis
- The study investigates a New Delhi Metallo-β-lactamase (NDM)-1-producing Klebsiella quasipneumoniae subsp. quasipneumoniae (KQPN) strain found in Brazil, addressing a gap in whole genome sequencing data for Enterobacterales in the region.
- Whole genome sequencing was performed on the isolated strain (A-73.113) to analyze its antimicrobial susceptibility and genetic features, identifying resistance to several antibiotics and the presence of various virulence and plasmid-encoding genes.
- The findings contribute to the understanding of antimicrobial resistance and the genetic makeup of this clinically significant strain, emphasizing the need for ongoing surveillance.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!