AI Article Synopsis
- Breast cancer subtype classification based on hormone receptors (HR) and HER2 is crucial for treatment decisions through immunohistochemistry.
- A retrospective study revealed different survival rates among breast cancer subtypes, showing HR(+)/HER2(-) patients had better overall survival compared to the triple negative subtype.
- Findings suggest that HR positive subtypes are more common and associated with longer survival rates compared to triple negative breast cancer.
Article Abstract
Background: Breast cancer subtype classification according to hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) using immunohistochemistry is the standard practice for therapeutic decision making.
Objective: To design future studies information on characteristics and survival of each subtype is essential.
Method: We conducted a retrospective study to analyze clinical and pathologic features as well as survival data according to breast cancer immunohistochemistry subtype.
Results: There were 211 women with a RH(+)/HER2(-) breast cancer subtype, 53 HR(+)/HER2(+), 16 HER2(+) and 23 HR(-)/HER2(-), with a median overall survival in months of 39 (20.5-62.7), 42 (25.5-65), 42 (13.7-67.7) and 26 (11-78), respectively, for a 3.7 hazard ratio of death (95% Confidence Interval [CI]: 1.3-10.3) for the triple negative group as compared to the HR(+)/HER2(-) group (p = 0.01).
Conclusions: HR positive subtypes by immunohistochemistry where most frequent and showed a greater overall survival compared to the triple negative subtype.
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| http://dx.doi.org/10.24875/GMM.19005133 | DOI Listing |
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