A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Efficacy and safety of Hou Gu Mi Xi in patients with spleen qi deficiency syndrome who underwent radical gastrectomy for gastric cancer: protocol for a multicenter, randomized, double-blind, placebo-controlled trial. | LitMetric

AI Article Synopsis

  • - The study focuses on Hou Gu Mi Xi (HGMX), a dietary TCM formula, to assess its effectiveness and safety in treating Spleen qi deficiency (SQD) in patients who have undergone radical gastrectomy for gastric cancer, which is a common postoperative issue.
  • - It's a multicenter, randomized, double-blind, placebo-controlled trial involving 130 participants for two years, measuring various outcomes like SQD symptoms, quality of life, performance status, body weight, and adverse events.
  • - The results may provide valuable evidence for HGMX as a potential complementary treatment for managing chronic complications after radical gastrectomy in gastric cancer patients.

Article Abstract

Background: Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This study aims to evaluate the efficacy and safety of HGMX in patients with SQD who have undergone radical gastrectomy for gastric cancer.

Methods And Design: This study is a multicenter, randomized, double-blind, placebo-controlled trial. One hundred thirty patients with SQD who have undergone radical gastrectomy for gastric cancer will be assigned to receive either HGMX or placebo for 2 years. The main outcome will be changes in SQD symptoms assessed by the Spleen Qi Deficiency Symptoms Grading and Quantifying Scale. The secondary outcomes will be changes in quality of life assessed by the Short Form 36 scale, performance status as assessed by the Eastern Cooperative Oncology Group Performance Status scale, body weight, and body mass index. Progression-free survival will also be assessed as a secondary outcome. Adverse events (AEs), severe AEs, and study withdrawal due to AEs will be recorded to evaluate the safety of HGMX.

Discussion: The results of this trial will provide initial evidence for the use of HGMX as an alternative and complementary intervention to manage chronic postoperative complications in patients who have undergone radical gastrectomy for gastric cancer.

Trial Registration: ClinicalTrials.gov, NCT03025152 . Registered on 17 January 2017.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558912PMC
http://dx.doi.org/10.1186/s13063-019-3429-xDOI Listing

Publication Analysis

Top Keywords

radical gastrectomy
20
gastrectomy gastric
16
spleen deficiency
12
undergone radical
12
efficacy safety
8
gastric cancer
8
multicenter randomized
8
randomized double-blind
8
double-blind placebo-controlled
8
placebo-controlled trial
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!