Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528618 | PMC |
| http://dx.doi.org/10.1021/acs.biochem.9b00438 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unlabelled: Trikafta is well-known for correcting the thermal and gating defects caused by the most common cystic fibrosis mutation F508del in the human cystic fibrosis transmembrane conductance regulator even at physiological temperature. However, the exact pathway is still unclear. Here, the noncovalent interactions among two transmembrane domains (TMD 1 and TMD2), the regulatory (R) domain and two nucleotide binding domains (NBD1 and NBD2), along with the thermoring structures of NBD1, were analyzed around the active gating center.
View Article and Find Full Text PDFRadiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7.
Am J Nucl Med Mol Imaging
October 2024
Department of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Metabotropic glutamate receptor 7 (mGlu) is a G protein-coupled receptor that is preferentially found in the active zone of neurotransmitter release in the central nervous system (CNS). mGlu plays a vital role in memory, learning, and neuronal development, rendering it a potential target for treating epilepsy, depression, and anxiety. The development of noninvasive imaging ligands targeting mGlu could help elucidate the functional significance of mGlu and accelerate drug discovery for neurological and psychiatric disorders.
View Article and Find Full Text PDFAuthor Correction: Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer.
Nat Commun
October 2024
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!