AI Article Synopsis
- The study aimed to explore how maternal alcohol consumption affects low birthweight (LBW) in infants.
- A thorough literature search resulted in 39 articles for a systematic review and 38 for a meta-analysis, revealing mixed results on the alcohol-LBW relationship across different study types.
- The analysis found no consistent association between alcohol consumption during pregnancy and LBW, highlighting significant variability in study outcomes likely due to differences in methodologies.
Article Abstract
Objective: To investigate the relationship between maternal exposure to alcohol and low birthweight (LBW).
Methods: The literature search was performed in January 2017 using the following electronic databases: Medline, Embase, LILACS, SciELO, Web of Science, Scopus, CINHAL, Proquest, and PsychInfo. The search strategy used the following terms: , , , , , , , , , and . No restrictions regarding language or publication date were considered. The literature search yielded 2,383 articles, and after screening and eligibility assessment, 39 articles were included in the systematic review, and 38 studies were included in the meta-analysis.
Results: Maternal alcohol consumption was associated with LBW among retrospective cohort studies (relative risk [RR] = 1.37; 95%CI [confidence interval]:1.10-1.77; I = 98.4%; < 0.01). Prospective cohort studies (RR = 1.11; 95%CI: 0.98-1.25; I = 81.5%; < 0.01), and case-control studies (odds ration [OR] = 1.16; 95%CI: 0.68-1.97; I = 61.2%; = 0.05) showed no association between alcohol and LBW. No publication bias was identified, and the meta-regression showed that the sample size influenced the high heterogeneity among retrospective cohort studies. The subgroup analysis showed differences in association between groups when compared by sample size, type of adjustment, or crude measures and publication year.
Conclusions: We have not found an association between alcohol consumption during gestation and LBW in the analysis in all of the subgroups. In addition, we have found a high heterogeneity between the primary studies, which is related to methodological differences in the conduction of these studies.
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| http://dx.doi.org/10.1055/s-0039-1688905 | DOI Listing |
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