AI Article Synopsis
- Researchers examined the midbrain area using transcranial sonography (TCS) to differentiate between Parkinson's Disease (PD) and progressive supranuclear palsy (PSP), considering the impact of disease duration on accuracy.
- In a study of 35 patients, the midbrain area was significantly larger in PD patients than in those with PSP, with findings showing strong statistical significance.
- Midbrain area proved to be the most reliable indicator for diagnosing PD, while the size of the third ventricle was more sensitive for identifying PSP, despite some overlap in findings.
Article Abstract
Objectives: We aimed to investigate the values of midbrain area in diagnosing Parkinson's Disease (PD) and progressive supranuclear palsy (PSP) by using transcranial sonography (TCS). Disease duration effect on brain sonographic findings could decrease the accuracy of TCS in PD and PSP patients. We reduced the disease duration effect on sonographic differences found between PD and PSP patients by using multivariate analysis.
Patients And Methods: Patients with clinical diagnosis of PSP and PD were recruited. We used SonoSite Edge II Ultrasound system to measure midbrain area, diameter of third ventricle and substantia nigra echogenicity. Diagnostic value of each measured area in sonography was estimated regarding its power for diagnosing PD or PSP. Independent sample t-test, Regression analysis and receiver operating characteristic (ROC) curve were performed using SPSS software.
Results: Of 35 patients, 18 were PD and 17 PSP cases. The mean midbrain area was 4.86 ± 0.71cm in PD patients and 3.61 ± 0.85cm in those with PSP (P < 0.005). Regression for reducing the effect of disease duration on midbrain area variances between patients with PD and PSP revealed a significant P value (P < 0.005, Adjusted R = 0.36). The sensitivity and specificity of midbrain area in diagnosing PD were 83.3% and 70.6% respectively. The sensitivity of the third ventricle size in diagnosing PSP was 82% although its specificity was 62%.
Conclusion: Midbrain area in patients with PD was wider than those with PSP that was not affected by disease duration. Midbrain area was the most accurate index for diagnosing PD by TCS although third ventricle size was the most sensitive one for diagnosing PSP.
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| http://dx.doi.org/10.1016/j.clineuro.2019.105383 | DOI Listing |
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