Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process.

Org Biomol Chem

Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, S.S. 554, Bivio per Sestu, I-09042, Monserrato, Cagliari, Italy.

Published: June 2019

An original tandem reaction consisting of a thermal elimination-addition process was developed. Highly substituted β-sulfinyl cyclobutane carboxylic acid derivatives were obtained from isomeric α-sulfinyl derivatives in a single operation in good to high yields and with high trans diastereoselectivity.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9ob00758jDOI Listing

Publication Analysis

Top Keywords

β-sulfinyl cyclobutane
8
cyclobutane carboxylic
8
synthesis β-sulfinyl
4
carboxylic amides
4
amides formal
4
formal sulphoxide
4
sulphoxide migration
4
migration process
4
process original
4
original tandem
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!