The fluorinated nucleoside dimers with a 1,2,3-triazole linkage are novel compounds within the field of bioorganic chemistry. We report on the synthesis and properties of two groups of nucleoside dimers analogs possessing a different arrangement of the 1,4-disubstituted 1,2,3-triazole linkage. Based on analysis of the , J, and J we estimated conformational preferences of sugar part and orientation around glycosidic bond. These compounds show moderate anticancer activity, with cytostatic studies in three different cancer cell lines.

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770.2019.1610891DOI Listing

Publication Analysis

Top Keywords

nucleoside dimers
12
123-triazole linkage
12
dimers analogues
4
analogues 123-triazole
4
linkage conjugation
4
conjugation floxuridine
4
floxuridine thymidine
4
thymidine novel
4
novel tools
4
tools cancer
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!