AI Article Synopsis
- This study details how imidazo[2,1-b][1,3,4]thiadiazoles are created from carbohydrates with specific D-ribo and D-xylo configurations.
- The newly synthesized compounds were tested to see how effective they are against the Junín virus, which causes Argentine hemorrhagic fever.
- Notably, the p-chlorophenyl derivatives showed promising antiviral activity at micromolar concentrations.
Article Abstract
Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.
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| http://dx.doi.org/10.1016/j.carres.2019.05.003 | DOI Listing |
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