FTIR spectra of niflumic acid in solid state, dissolved in CCl and adsorbed on silica or alumina surface, as well as their temperature dependence, provide information about different stages of aggregation: monomers, dimers, amorphous and crystalline solid phase, as well as about perturbation of the molecule by the surface. The spectra observed are compared with those obtained by quantum mechanical calculations. The luminescence spectra are less sensitive to the aggregation, they differ mostly in the intensity, while the position of maximum at about 440 nm remains almost the same.
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http://dx.doi.org/10.1016/j.saa.2019.117224 | DOI Listing |
Biomacromolecules
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
J Enzyme Inhib Med Chem
December 2024
College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Transcriptional enhanced associate domain (TEAD) transcription factors undergo auto-palmitoylation, which is critical to mediate their function and maintain stability. Targeting the palmitate binding pocket of TEAD holds considerable promise for drug discovery, and it can be characterised into three components: a conserved cysteine, a hydrophobic main pocket, and a hydrophilic side pocket. Endogenous palmitate and several known TEAD inhibitors interact with the cysteine and hydrophobic residues in the deep hydrophobic pocket.
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland.
The objective of our research was to determine the effects of xanthohumol (XN), a flavonoid isolated from hops (), and the anti-inflammatory drug niflumic acid (NA), separately and in combination with each other, on the proliferation of human cancer cells. Additionally, so as to understand the mechanism underlying the anticancer properties of the tested compounds, their effects on the biophysical parameters of a model membrane were assessed. The cells were incubated with XN and NA at various concentrations, either individually or in combination with each other.
View Article and Find Full Text PDFSci Rep
October 2024
Shashi Town Health Center, Shaodong, 422813, Hunan, China.
Pharmaceutics
September 2024
Chemical Engineering Laboratory, Process Engineering Department, Faculty of Technology, University of Blida 1, Road of Soumaa, BP 270, Blida 09000, Algeria.
Although niflumic acid (NA) is one of the most used non-steroidal anti-inflammatory drugs, it suffers from poor solubility, low bioavailability, and significant adverse effects. To address these limitations, the complexation of NA with cyclodextrins (CDs) is a promising strategy. However, complexing CDs with low molecular weight drugs like NA can lead to low CE.
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