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Background: Lung transplantation is the treatment of choice for end-stage nonmalignant lung disease. It has become a routine procedure through advances in donor lung preservation, extracorporeal membrane oxygenation, immunosuppression, intensive care medicine, and follow-up care.
Methods: This review is based on publications about lung transplantation that were retrieved by a selective literature search, and on the procedures and experience of two large-volume lung transplantation centers.
ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature.
Xenotransplantation
November 2024
Division of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.
Introduction: Although there is a plethora of literature on electrocardiographic changes following cardiac allotransplantation, there is little in the field of cardiac xenotransplantation. The only published literature to date is that of the first pig-to-human cardiac xenotransplantation. Here we take a close look at the electrocardiographic parameters in four non-human primate recipients of orthotopic cardiac xenotransplantation to develop baseline metrics for comparison.
View Article and Find Full Text PDFHeterologous Materials Are Really Better than Autologous in Tympanoplasty Mastoid Obliteration? A Systematic Review with Meta-Analysis.
J Int Adv Otol
September 2024
Department of Otolaryngology University of Siena, Siena, Italy.
Article Synopsis
- - The study reviews literature from the past decade on mastoid obliteration in adults, comparing outcomes of autologous (patient's own tissue) vs. heterologous (donor tissue) grafts, using data from various medical databases.
- - A total of 37 studies were included, focusing on long-term results (over 12 months), highlighting that neither technique is definitively better, but both have unique benefits in cholesteatoma surgery.
- - The findings reveal that while heterologous grafts generally show lower rates of recurrent cholesteatoma, they have higher rates of complications like otorrhea and tympanic membrane perforations, illustrating a trade-off between the two graft types.
Challenges in Paediatric Xenotransplantation: Ethical Components Requiring Distinct Attention in Children and Obligations to Patients and Society.
J Bioeth Inq
October 2024
Department of Family Medicine, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.
The transplantation of non-human organs into humans, or xenotransplantation (XTx), has recently garnered new attention and is being developed to help address the problem of organ scarcity in transplantation. Ethical issues surrounding XTx have been studied since initial interest arose decades ago and have experienced renewed discussion in the literature. However, the distinct and relevant differences when applied to children has largely been overlooked with few groups attending to the concerns that XTx in children raises.
View Article and Find Full Text PDFQuercetin 7-rhamnoside from Sorbaria sorbifolia exerts anti-hepatocellular carcinoma effect via DHRS13/apoptotic pathway.
Phytomedicine
December 2024
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, China. Electronic address:
Background: Previous research demonstrated the effects of Sorbaria sorbifolia (SS) in combating hepatocellular carcinoma (HCC). Despite SS's proven efficacy in treating HCC, the precise bioactive constituents contributing to its therapeutic benefits, along with the mechanisms behind them, warrant further exploration.
Purpose: The objective of our study was to illuminate the possible elements, targets, and modulatory pathways employed by specific bioactive components in SS for HCC treatment.
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