In this study, Guangdong Han population was analyzed with Goldeneye™ DNA ID 22NC Kit containing 20 non-CODIS STR loci and a CODIS STR locus. In 503 unrelated individuals, a total of 232 alleles and 813 genotypes were observed. The values of polymorphism information content (PIC), expected heterozygosity (He), and observed heterozygosity (Ho) ranged from 0.6678 to 0.8618, 0.7197 to 0.8757, and 0.6938 to 0.8767, respectively. No deviation from Hardy-Weinberg equilibrium was observed at all loci after the Bonferroni correction. The combined power of discrimination and the combined power of exclusion were 0.999999999999999999999999937051 and 0.999999998467033, respectively. Population comparison revealed that Guangdong Han population was relatively close to Huadong Han population. These results suggested that the 21 STR loci are highly polymorphic and Goldeneye™ DNA ID 22NC Kit is suitable for individual identification and paternity testing in Guangdong Han population.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s00414-019-02094-1 | DOI Listing |
Clin Exp Nephrol
January 2025
Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: Previous studies have suggested a potential role of estrogen in the pathophysiology of chronic kidney disease (CKD); however, the association and causality between estrogen and kidney function remain unclear.
Methods: The cross-sectional correlation between serum estradiol concentration and estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) was analyzed using data from the National Health and Nutrition Examination Survey 2013-2016. Causality was tested using mutual bidirectional Mendelian randomization (MR) approaches based on six large-scale GWAS studies.
Geroscience
January 2025
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ageing is the primary driver of age-associated chronic diseases and conditions. Asian populations have traditionally been underrepresented in studies understanding age-related diseases. Thus, the Ageing BIOmarker Study in Singaporeans (ABIOS) aims to characterise biomarkers of ageing in Singaporeans, exploring associations between molecular, physiological, and digital biomarkers of ageing.
View Article and Find Full Text PDFJ Dairy Sci
January 2025
Department of Interventional Radiology, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei Province, China; Department of Interventional Radiology, Yichang Central People's Hospital, Yichang 443003, Hubei Province, China. Electronic address:
There is currently a lack of research examining the association between the consumption of different dairy products and type 2 diabetes (T2D) in East Asian populations. To address this gap, the present study employs Mendelian randomization (MR) to investigate the potential impact of 3 different types of milk consumption (including whole milk, semi-skim milk, and skim milk) on the risk of developing T2D. The results indicate that both whole milk and skim milk are associated with an increased risk of T2D (whole milk: OR = 1.
View Article and Find Full Text PDFAm J Prev Med
January 2025
Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia.
Introduction: This study aimed to examine the association of county-level racial and economic residential segregation with mortality rates in the U.S. between 2018 and 2022.
View Article and Find Full Text PDFJ Ren Nutr
January 2025
Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Objective: This large cohort study aimed to examine the overall associations of physical activity (PA) and estimated cardiorespiratory fitness (eCRF) with incident chronic kidney disease (CKD).
Methods: This study included a total of 274,292 participants (mean age, 37.9±8.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!