In this study, two phenol compounds, magnolol and honokiol, were extracted from and identified by LC-MS, H- and C-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including (Fr.) Keissl, (Link) Thom, f.sp. solani, J. Sheld, Schltdl., Miyabe & G. Yamada, and J.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and honokiol. The results showed that they inhibited the growth of in a dose-dependent manner. Moreover, magnolol and honokiol treatment resulted in distorted mycelia and increased the cell membrane permeability of , as determined by conductivity measurements. These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.
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| http://dx.doi.org/10.3390/molecules24112140 | DOI Listing |
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