Amplitude of Accommodation in Patients with Multiple Sclerosis.

: To evaluate the effect of multiple sclerosis (MS) on the amplitude of accommodation (AA) and retinal nerve fiber layer (RNFL) thickness.: A total of 25 MS patients with visual-evoked potential (VEP) abnormalities (MS/+VEP Group), 25 MS patients without VEP abnormalities (MS/-VEP Group), and 25 controls (Control Group) were enrolled. Only findings from the right eye of the participants were included in the analysis. Each participant underwent a pattern-reversal visual-evoked potential (PVEP) recording, an RNFL thickness analysis by optic coherence tomography (OCT) in all quadrants, and a measurement of amplitude of accommodation (AA) with minus lens technique. The AA and the RNFL thickness were compared between the groups.: The mean age and sex distributions did not differ significantly across the groups (= .788, = .906, respectively). The mean AA was 5.36 ± 0.7 D in MS/+VEP group, 6.06 ± 1.4 D in MS/-VEP group, and 6.4 ± 0.9 D in control group (= .002). The difference in the mean AA values between MS/+VEP and control groups were significant ( = .002). AA was significantly correlated with age, P100 latency and amplitude values in MS/+VEP group ( = -0.832, < .001; = -0.596, = .002 and = 0.498, = .011, respectively). In a multivariable regression model, age and P100 latency were significant parameters for affecting AA in patients with MS ( < .001 and = .001). In another multivariable regression model, age and average RNFL thickness were significant parameters for affecting AA in patients with MS ( < .001 and = .010).: We found that the AA was lower in MS patients with VEP abnormalities compared to age-matched healthy individuals. P100 latency was a significant parameter for predicting AA in MS/+VEP group. These results suggest that MS patients with VEP abnormalities might experience presbyopia earlier in life than people without MS, probably due to the chronic demyelination of neural pathways.