Orbital angular momentum (OAM), one fundamental property of light, has been of great interest over the past decades. An ideal OAM generator, fully compatible with existing physical dimensions (wavelength and polarization) of light, would offer the distinct features of broadband, polarization diversity, and ultra-compact footprint. Here, we propose, design, fabricate, and demonstrate an ultra-compact chip-scale broadband polarization diversity OAM generator on a silicon platform with a 3.6 × 3.6 μm footprint. The silicon OAM chip is formed by introducing a subwavelength surface structure (superposed holographic fork gratings) on top of a silicon waveguide, coupling the in-plane waveguide mode to the out-plane free-space OAM mode. We demonstrate in theory and experiment the broadband generation of polarization diversity OAM modes (x-/y-polarized OAM/OAM) from 1500 to 1630 nm with high purity and efficiency. The demonstrations of an ultra-compact broadband polarization diversity OAM generator may open up new perspectives for OAM-assisted N-dimensional optical multiplexing communications/interconnects and high-dimensional quantum communication systems.
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http://dx.doi.org/10.1126/sciadv.aau9593 | DOI Listing |
MedComm (2020)
February 2025
Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity and plasticity, challenging the traditional view of neutrophils as a homogeneous population with a limited functional repertoire. Advances in single-cell technologies and functional assays have revealed distinct neutrophil subsets with diverse phenotypes and functions and their ability to adapt to microenvironmental cues.
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January 2025
Experimental Pathology Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico.
It was a general belief that drug resistance in Mycobacterium tuberculosis (Mtb) was associated with lesser virulence, particularly rifampicin resistance, which is usually produced by mutations in the RNA polymerase Beta subunit (RpoB). Interestingly, this kind of bacterial mutations affect gene transcription with significant effects on bacterial physiology and metabolism, affecting also the bacterial antigenic constitution that in consequence can produce diverse immune responses and disease outcome. In the present study, we show the results of the Mtb clinical isolate A96, which is resistant to rifampicin and when used to infect BALB/c mice showed hypervirulence, apparently by rapidly polarization of the Th2 immune response through early and high production of IL-4.
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March 2025
Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan. Electronic address:
Starch-derived hydrophilic malto-oligosaccharides (Glc, where n = 1-7) conjugated to hydrophobic solanesol through click chemistry, i.e., Glc-b-Sol copolymers, have demonstrated significant promise in developing fully natural block co-oligomers for solid-state nanopatterning applications.
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January 2025
Instituto Tecnológico de Chascomús (CONICET-UNSAM), Av. Intendente Marino Km 8.2, CC 164, B7130IWA Chascomús, Argentina; Escuela de Bio y Nanotecnologías (UNSAM), Argentina. Electronic address:
β-carbolines (βCs) represent a large family of bioactive alkaloids, including norharmane and normelinonine F, known for their diverse pharmacological activities. The effects of these alkaloids may depend, among other factors, on their delivery, accumulation in different subcellular compartments, and interactions with biomacromolecules such as serum albumins. In this study, we investigated the pH dependence of the interactions between bovine serum albumin (BSA) and four βCs (norharmane, normelinonine F, and their corresponding N(9)-methyl derivatives) using UV-vis and fluorescence spectroscopy, combined with multivariate analysis and molecular docking.
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January 2025
Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address:
Covalent organic frameworks (COFs) are a class of porous crystalline materials with high surface areas, tunable pore sizes, and customizable surface chemistry, making them ideal for selective metal ion separation. This review explores the nanoarchitectonics, mechanisms, and applications of COFs in metal ion separation. We highlight the diverse bonding types (e.
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