AI Article Synopsis
- - Genetic correlation refers to the genetic link between two traits, helping to identify shared biological pathways or causative relationships between them.
- - Traditional methods struggled to estimate these correlations due to the lack of large family datasets, especially with disease traits.
- - Recent advancements in genomic techniques, like genome-wide association studies, now enable the estimation of genetic correlations for almost any trait pair, especially in the context of human diseases.
Article Abstract
The genetic correlation describes the genetic relationship between two traits and can contribute to a better understanding of the shared biological pathways and/or the causality relationships between them. The rarity of large family cohorts with recorded instances of two traits, particularly disease traits, has made it difficult to estimate genetic correlations using traditional epidemiological approaches. However, advances in genomic methodologies, such as genome-wide association studies, and widespread sharing of data now allow genetic correlations to be estimated for virtually any trait pair. Here, we review the definition, estimation, interpretation and uses of genetic correlations, with a focus on applications to human disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41576-019-0137-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!