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Nanocarrier-mediated cancer therapy with cisplatin: .
Heliyon
April 2024
Institute for Health and Sport, College of Health and Medicine, Victoria University, Melbourne, Victoria, Australia.
Aims: Cisplatin is a frontline chemotherapeutic utilized to attenuate multiple cancers in the clinic. Given its side-effects, a new cisplatin formulation which could prevent cytotoxicity, metabolic deficiencies and metastasis is much needed. This study investigates whether nanocarriers can provide a better mode of drug delivery in preclinical cancer models seeking a potent anticancer therapeutic agent.
View Article and Find Full Text PDFThe efficacy of second-line chemotherapy for advanced biliary tract cancer: A systematic review and network meta-analysis.
J Hepatobiliary Pancreat Sci
January 2025
Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon, Korea.
Background: This network meta-analysis (NMA) aims to provide evidence-based guidance for selecting the second-line chemotherapy for biliary tract cancer (BTC).
Methods: A comprehensive literature search was conducted on PubMed, Cochrane, and EMBASE through July 2024. Inclusion criteria involved: (1) patients underwent second-line chemotherapy following platinum-based first-line therapy, (2) intervention/comparator groups consisted of various chemotherapeutic agents, and (3) outcomes measured as hazard ratio (HR) of overall survival (OS) and progression-free survival (PFS) in randomized controlled trials (RCTs) and cohort studies.
Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent-In Vitro and In Vivo Studies.
Pharmaceutics
December 2024
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
The therapeutic management of melanoma, the most aggressive form of skin cancer, remains challenging. In the search for more effective therapeutic options, metal-based complexes are being investigated for their anticancer properties. Cisplatin was the first clinically approved platinum-based drug and, based on its success, other metals (e.
View Article and Find Full Text PDFReal-World Evidence on the Effectiveness of Pembrolizumab in Patients With Recurrent/Metastatic/Unresectable Head and Neck Squamous Cell Cancer: A Systematic Review and Meta-Analysis.
Cureus
January 2025
Biostatistics, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
The aim of the review was to systematically review real-world data on the effectiveness and safety of pembrolizumab in recurrent/metastatic/unresectable head and neck squamous cell cancer (HNSCC) patients. Two independent reviewers retrieved the studies separately and simultaneously. PubMed, Embase, Scopus, Web of Science, and Cochrane Central were searched for prospective and retrospective studies on recurrent/metastatic/unresectable HNSCC patients treated with either pembrolizumab monotherapy or pembrolizumab combination therapy published till November 2024.
View Article and Find Full Text PDFDual-Driven Activation of High-Valence States in Prussian Blue Analogues Via Graphene-Quantum Dots and Ozone-Induced Surface Restructuring for Superior Hydrogen Evolution Electrocatalyst.
Small Methods
January 2025
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan.
Electrochemical water splitting is a pivotal process for sustainable hydrogen energy production, relying on efficient hydrogen evolution reaction (HER) catalysts, particularly in acidic environments, where both high activity and durability are crucial. Despite the favorable kinetics of platinum (Pt)-based materials, their performance is hindered under harsh conditions, driving the search for alternatives. Due to their unique structural characteristic, Prussian blue analogs (PBAs) emerge as attractive candidates for designing efficient HER electrocatalysts.
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