Development of low-cost hybrid multi-walled carbon nanotube-based ammonia gas-sensing strips with an integrated sensor read-out system for clinical breath analyzer applications.

This work demonstrates the development of Ag@polyaniline/multi-walled carbon nanotube nanocomposite-based sensor strips and a suitable integrated electronic read-out system for the measurement of trace-level concentrations of ammonia (NH). The sensor is optimized under various operating conditions and the resulting sensor exhibited an enhanced response (32% for 2 ppm) with excellent selectivity. Stable performance was observed towards NH in the presence of high concentrations of CO (>40 000 ppm), simulated and real breath samples. A suitable electronic sensor read-out system has also been designed and developed based on multi-scale resistance-to-voltage conversion architecture, processed by a 32-bit microcontroller which is operatable over a wide range of sensor resistance (1 kΩ to 200 MΩ). As a proof of concept, integration of gas-sensing strips with the electronic read-out system was tested with various levels of NH (<2 ppm as normal, >2 ppm as critical and 2 ppm as threshold), which is important for clinical breath analyzer applications. The developed prototype device can be readily incorporated into a portable, low-cost and non-invasive point-of-care breath NH detection unit for portable pre-diagnostic breath analyzer applications.