AI Article Synopsis
- - The study focuses on the role of biomarkers in diabetic kidney disease (DKD) in Type 2 diabetes patients who show normal levels of albumin but have a low estimated glomerular filtration rate (eGFR).
- - Out of 200 patients, 28 (14%) were found to have a low eGFR, with notable increases in the levels of biomarkers IL-18, VCAM-1, and P-selectin associated with this condition.
- - The findings suggest that these biomarkers have significant diagnostic value and could help predict early DKD, indicating a need for further research to validate these results.
Article Abstract
To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). In this cross-sectional study of 200 normoalbuminuric Type 2 diabetes patients, 28 patients (14%) had a low eGFR. The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Among normoalbuminuric Type 2 diabetes patients, IL-18, VCAM-1 and P-selectin may play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.
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| http://dx.doi.org/10.2217/bmm-2018-0359 | DOI Listing |
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