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| http://dx.doi.org/10.2486/indhealth.57_300 | DOI Listing |
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Clinical Manifestations.
Alzheimers Dement
December 2024
Rutgers Institute for Health, Health Care Policy, and Aging Research, New Brunswick, NJ, USA.
Background: Early identification of preclinical Alzheimer's disease (AD) is key to timely interventions. However, existing neuropsychological test scores are not sensitive to subtle cognitive decline during preclinical AD. There is a need to develop cognitive measures that are more sensitive to early stages of decline.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Olfactory impairment represents an early sensory marker of neurodegeneration, but little is known about how interindividual differences in the trajectories of olfactory change relate to dementia conversion. We aimed to characterize olfactory decline profiles during phases of normal cognition to assess their predictive value for dementia conversion.
Method: Olfactory trajectory profiles of dementia-free persons (SNAC-K; n = 1601; mean age = 70.
Clinical Manifestations.
Alzheimers Dement
December 2024
University of Calgary, Calgary, AB, Canada.
Background: Agitation in dementia is associated with poor outcomes, including mortality. However, the lack of a consensus definition of agitation has hampered research, historically driven by variable approaches to symptom identification. Accordingly, prevalence estimates range widely (5%-88%) and interventions are hard to compare meaningfully.
View Article and Find Full Text PDFTypical biosensing platforms are based on the "lock-and-key" approach, providing high specificity and sensitivity for environmental and food safety monitoring. However, they are limited in their ability to detect multiple analytes simultaneously. With the use of pattern identification methods, biosensor arrays can detect faint fluctuations caused by multiple analytes with similar properties in complex systems.
View Article and Find Full Text PDFOptimizing Triage in Chemical Disasters: Validation of Modified IGSA Criteria for Hydrofluoric Acid Exposure.
Disaster Med Public Health Prep
January 2025
Department of Emergency Medicine, Soonchunhyang University Gumi Hospital, Republic of Korea.
Objective: This study aimed to develop and validate the modified irritant gas syndrome agent (IGSA) criteria, utilizing readily available triage information and epidemiologic data to efficiently segregate patients based on the severity of hydrofluoric acid (HFA) exposure.
Methods: A retrospective analysis of 160 patients exposed to HFA was performed to develop the criteria and assess the criteria's efficacy, focusing on age, respiratory rate, and compliance with IGSA standards. The criteria's validity was assessed by comparing clinical outcomes between patients meeting the modified IGSA (mIGSA) criteria and those who did not as external and internal.
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