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Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy.
Ann Clin Biochem
November 2021
Hallands Sjukhus Halmstad, Halmstad, Sweden.
Background: The revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage (UK) provide an objective means of assessing cerebrospinal fluid samples to determine the risk of subarachnoid haemorrhage. The guidelines are intended for general use, but samples rendered uninterpretable due to the presence of the antibiotic doxycycline have been described. Here, further cases of antibiotic-based interference, and their implications, are presented.
View Article and Find Full Text PDFEXPRESS: Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy.
Ann Clin Biochem
June 2021
Hallands sjukhus Halmstad, Halmstad, Sweden.
Background The revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage (UK) provide an objective means of assessing cerebrospinal fluid (CSF) samples to determine risk of subarachnoid haemorrhage (SAH). The guidelines are intended for general use, but samples rendered uninterpretable due to the presence of the antibiotic doxycycline have been described. Here, further cases of antibiotic- based interference, and their implications, are presented.
View Article and Find Full Text PDFStudy protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success.
BMC Pediatr
April 2020
Newborn Care Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
Background: The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20-50%) rates. Lumbar puncture (LP) remains essential to the diagnosis of meningitis. Though LP is a common procedure in neonates, success rates are lower (50-60%) than in other patient populations.
View Article and Find Full Text PDFValidation of a New Rapid Detection Test for Detection of Neisseria meningitidis A/C/W/X/Y Antigens in Cerebrospinal Fluid.
J Clin Microbiol
February 2020
Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci and Haemophilus influenzae, Paris, France.
Meningococcal meningitis remains a life-threatening disease worldwide, with high prevalence in the sub-Saharan meningitis belt. A rapid diagnosis is crucial for implementing adapted antimicrobial treatment. We describe the performances of a new immunochromatographic test (MeningoSpeed, BioSpeedia, France) for detecting and grouping Cerebrospinal fluids (CSFs) were collected from 5 African countries and France.
View Article and Find Full Text PDFUninterpretable cerebrospinal fluid absorbance scan caused by doxycycline therapy.
Ann Clin Biochem
September 2019
Hallands Sjukhus Halmstad, Halmstad, Sweden.
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