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Microbial Primer: Microbiome and thermal tolerance - a new frontier in climate resilience?
Microbiology (Reading)
January 2025
Department of Zoology, University of British Columbia, Vancouver, Canada.
Microbiome-animal host symbioses are ubiquitous in nature. Animal-associated microbiomes can play a crucial role in host physiology, health and resilience to environmental stressors. As climate change drives rising global temperatures and increases the frequency of thermal extremes, microbiomes are emerging as a new frontier in buffering vulnerable animals against temperature fluctuations.
View Article and Find Full Text PDFDesigned Synthesis of Amino-Azo-Quinoline and their Nickel(II) Complexes: Molecular Structure, Electrochemistry and an Insight into their in vitro Anti-Cancer Activities.
Chem Biodivers
January 2025
St Xavier's College, Kolkata, Department of Chemistry, 30, Mother teresa Sarani, Kol-16, 700016, Kolkata, INDIA.
Amino-quinolines are potential candidates that may provide some insight into the current chemotherapeutic research due to their demonstrated anti-cancer activity. This led us to synthesize and explore a new amino-azo-quinoline ligand H2L 1 and its square planar nickel(II) complexes [Ni(HL)(OAc)], 2 and [Ni(HL)Cl], 3 and the structures were determined by SCXRD. Theoretical investigation of redox orbitals of the complexes discloses that the reduction process is due to ligand reduction whereas both metal and ligand are contributing towards oxidation.
View Article and Find Full Text PDFCausal Inference With Observational Data and Unobserved Confounding Variables.
Ecol Lett
January 2025
Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, Colorado, USA.
Experiments have long been the gold standard for causal inference in Ecology. As Ecology tackles progressively larger problems, however, we are moving beyond the scales at which randomised controlled experiments are feasible. To answer causal questions at scale, we need to also use observational data -something Ecologists tend to view with great scepticism.
View Article and Find Full Text PDFResearch on the infiltration law and enhancing application of dust suppressants in powder materials.
J Air Waste Manag Assoc
January 2025
School of Emergency Management and Safety Engineering, China University of Mining and Technology (Beijing), Beijing, China.
Dust emissions from open-pit mining pose a significant threat to environmental safety and human health. Currently, the range of dust suppressants used in coal mining is limited, often failing to account for their suitability across various stockpiles. This oversight results in poor infiltration after application, leading to insufficient crust formation and reduced durability.
View Article and Find Full Text PDFThe Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases.
Invest Ophthalmol Vis Sci
January 2025
John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States.
Ever since the US Food and Drug Administration (FDA) approved the first vascular endothelial growth factor (VEGF) antagonist 2 decades ago, inhibitors of VEGF have revolutionized the treatment of a variety of ocular disorders involving pathologic neovascularization and retinal exudation. In this perspective, we evaluate the current status of anti-VEGF therapies and the real-world challenges encountered with maintaining therapeutic outcomes. Finally, we describe novel VEGF-based and combinatorial approaches that are in clinical development.
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