This study aimed to investigate the association between the characteristics of the environment related to physical activity and income in areas around schools in Curitiba, Paraná State, Brazil. A total of 888 street segments were audited with a systematic observation instrument in three sections (Routes, Segments, and Crossings) in a radius of 500 meters around 30 public schools. The total score was the sum of the sections. Data on income in the school neighborhood were obtained from the 2010 Population Census, and the linear distance from each school to the city center was calculated. Multilevel models (level one = segment; level two = school) were applied to the analysis, with estimates of weighted means and intraclass correlation coefficients (ICC). In the crude analysis, the highest variability between schools was observed in the Segments section (ICC = 0.41) and the lowest in the Routes section (ICC = 0.19). The street segments located around schools in the lowest income tertile reach an adjusted mean total score of 15.6 (95%CI: 13.0-18.3), nearly half of that in those with the highest income, which reached 30.7 points (95%CI; 28.0-33.5), with a significant difference between the tertiles (p < 0.001). The score for the more central areas of the city was 30.1 (95%CI: 26.9-33.4), significantly higher (p < 0.001) than for the more peripheral areas, where the score was 16.3 (95%CI: 12.8-19.8). The characteristics of the environment assessed by the Routes and Segments sections, in addition to the total score, were associated with the lowest income. An environment with worse quality in lower income areas is one of the iniquities that needs to be faced in Brazil's metropolises in order to help improve the people's health.
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http://dx.doi.org/10.1590/0102-311x00110218 | DOI Listing |
Ann Surg
January 2025
Center for Surgical Science, Zealand University Hospital, Køge, Denmark.
Objective: This study investigated the association between loss of MSH2/MSH6 versus loss of MLH1/PMS2 expression and overall survival and disease-free survival in patients with localized colorectal cancer.
Background: The risk of developing colorectal cancer varies depending on the expression of mismatch repair proteins. However, it is unknown if the prognosis differs accordingly.
Stroke
January 2025
Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan (M.T., T.N., S.A., H.M.).
Background: Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 values, proton density, and myelin volume, in a single scan. Although the usefulness of myelin measurement with synthetic MRI has been reported for assessing several diseases, investigations in patients with stroke have not been reported. We aimed to explore the utility of myelin quantification using synthetic MRI in predicting outcomes in patients with acute ischemic stroke.
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December 2024
Servicio de Análisis Clínicos, Hospital Universitario Santa Lucía, Cartagena, Murcia, España.
Objective: To analyze the usefulness of mean mid-regional pro-adrenomedullin (MR-proADM) level to stratify risk in emergency department patients with solid tumors attended for febrile neutropenia after chemotherapy. To compare risk prediction with MR-proADM to that of conventional biomarkers and scores on the Multinational Association for Supportive Care in Cancer (MASCC) score.
Methods: Prospective observational cohort study enrolling patients with solid tumors who developed febrile neutropenia after chemotherapy.
Emergencias
December 2024
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seúl, República de Corea. Department of Digital Health, SAIHST, Sungkyunkwan University, Seúl, República de Corea.
Objective: To develop a Metabolic Derangement Score (MDS) based on parameters available after initial testing and assess the score's ability to predict survival after out-of hospital cardiac arrest (OHCA) and the likely usefulness of extracorporeal life support (ECLS).
Methods: A total of 5100 cases in the Korean Cardiac Arrest Research Consortium registry were included. Patients' mean age was 67 years, and 69% were men.
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