AI Article Synopsis

  • Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases characterized by itchy skin rashes and blisters, primarily driven by IgA antibodies, with mucosal lesions seen only in linear IgA bullous dermatosis.
  • The text discusses a consensus on the treatment of these conditions in Brazil, including a review of current literature and comparison with the authors' experiences.
  • Dermatitis herpetiformis is linked to celiac disease and can be managed with a gluten-free diet and dapsone, while linear IgA bullous dermatosis may need dapsone along with corticosteroids or immunosuppressants for effective treatment.

Article Abstract

Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors' experience, aiming at the treatment orientation of these diseases in Brazil. Dermatitis herpetiformis is a cutaneous manifestation of celiac disease, and can be controlled with a gluten-free diet and dapsone. On the other hand, linear IgA bullous dermatosis arises spontaneously or is triggered by drugs, and can be controlled with dapsone, but often requires the association of systemic corticosteroids and eventually immunosuppressants.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544034PMC
http://dx.doi.org/10.1590/abd1806-4841.2019940208DOI Listing

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