AI Article Synopsis
- Lymphatic metastasis is crucial for understanding cancer progression and can impact treatment outcomes.
- Conventional chemotherapy struggles to effectively target lymphatic systems without causing harmful side effects.
- New formulation and nanomedicine strategies show promise in enhancing drug delivery to lymphatic cancers, but there are still significant challenges in translating these improvements into better treatment results.
Article Abstract
Lymphatic metastasis plays an important role in cancer progression and prognosis. However, conventional small-molecule chemotherapy drugs inefficiently access the lymphatic system, making the effective eradication of lymphatic metastases difficult without dose-limiting toxicity. Various formulation and nanomedicine-based approaches can be used to significantly enhance the trafficking of small-molecule, peptide and protein drugs toward the lymphatic system to enhance drug exposure at sites of lymphatic cancer growth. However, a number of obstacles exist in translating improved lymphatic exposure into improved chemotherapeutic outcomes. This review highlights the opportunities and challenges inherent in employing formulation and nanomedicinal approaches to improve chemotherapeutic drug activity within the lymphatic system and, importantly, at sites of lymphatic cancer metastasis.
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| http://dx.doi.org/10.2217/nnm-2018-0478 | DOI Listing |
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