Fluorescence detection of glutathione S-transferases in a low GSH level environment.

Chem Commun (Camb)

Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an, Shanxi 710032, P. R. China.

Published: June 2019

Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a low GSH level environment by pre-treatment of the cells with thiol-scavengers.

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Source
http://dx.doi.org/10.1039/c9cc02702eDOI Listing

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