Isocyanide-based multicomponent reactions are a versatile tool in the synthesis of heterocycles. This review describes recently developed approaches based on the combination of consecutive or repetitive isocyanide-based multicomponent reactions for the synthesis of structurally diverse heterocycles. These strategies have also allowed the synthesis of a plethora of macroheterocycles in a reduced number of steps.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541343 | PMC |
| http://dx.doi.org/10.3762/bjoc.15.88 | DOI Listing |
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