AI Article Synopsis
- New research in humans and mice indicates that transforming growth factor-β (TGF-β) plays a significant role in the onset and progression of allergic diseases, as well as in resulting tissue damage.
- TGF-β influences T cell activation and differentiation, as well as B cell immunoglobulin class switching when the body first encounters allergens.
- It also affects mast cells during allergic reactions, impacting response intensity and promoting tissue remodeling post-allergic damage; genetic changes that disrupt TGF-β signaling can lead to higher incidences of allergies.
Article Abstract
New evidence in humans and mice supports a role for transforming growth factor-β (TGF-β) in the initiation and effector phases of allergic disease, as well as in consequent tissue dysfunction. This pleiotropic cytokine can affect T cell activation and differentiation and B cell immunoglobulin class switching following initial encounter with an allergen. TGF-β can also act on mast cells during an acute allergic episode to modulate the strength of the response, in addition to driving tissue remodeling following damage caused by an allergic attack. Accordingly, genetic disorders leading to altered TGF-β signaling can result in increased rates of allergic disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800617 | PMC |
| http://dx.doi.org/10.1016/j.coi.2019.05.002 | DOI Listing |
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