The application of toxic solvents and additives is inevitable for most of the described protocols for F-labeling. Herein, a novel "green" procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of F-labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.
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| http://dx.doi.org/10.1002/jlcr.3776 | DOI Listing |
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