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Approaches to patients with obesity and CKD: focus on nutrition and surgery.
Clin Kidney J
December 2024
Nephrology Division, University "Luigi Vanvitelli" of Naples, Naples, Italy.
Obesity is recognized as a public health challenge. During the last three decades, the global age-standardized prevalence increased from 8.8% to 18.
View Article and Find Full Text PDFInvestigating the impact of ketogenic diets.
Elife
October 2024
Institut de Biologie de l'École Normale Supérieure, École Normale Supérieure, CNRS UMR 8197, INSERM U1024, Université Paris Sciences et Lettres, Paris, France.
Exposure to ketone bodies in early development can reduce neurological impairments in a strain of the nematode with PTEN defects.
View Article and Find Full Text PDFThe gut microbiota changed by ketogenic diets contribute to glucose intolerance rather than lipid accumulation.
Front Endocrinol (Lausanne)
October 2024
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Article Synopsis
- The ketogenic diet (KD) affects body weight management but its impact on glucose and lipid metabolism is still unclear; this study examines how different types of KDs influence gut microbiota and metabolic changes in mice.
- Two KDs, KD1 and KD2, led to glucose intolerance in mice, with KD1 linked to obesity symptoms and KD2 causing weight loss but severe fat buildup in the liver and impaired fatty acid metabolism.
- The research shows that both KDs altered gut microbiota, reduced short-chain fatty acids, and that depleting gut microbiota with antibiotics reduced glucose metabolism disturbances, suggesting gut microbes play a key role in KD-related glucose intolerance.
Fueling Recovery: The Therapeutic Role of Ketogenic Diet in Neurological Pathologies.
Cureus
September 2024
General Surgery, Shaikh Zayed Medical Complex, Lahore, PAK.
The ketogenic diet (KD) has gained a lot of attraction in the management of neurological disorders. KD therapies are high-fat, low-carbohydrate diets intended to shift energy consumption and metabolism from carbohydrates to fat in ketogenesis. The oxidative phosphorylation of ketone bodies generates energy packets for body cells, especially the central nervous system, replacing the role of glucose.
View Article and Find Full Text PDFUnraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability.
Front Pharmacol
September 2024
Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly recognized for its intricate relationship with mitochondria, the cellular powerhouses responsible for energy production and calcium regulation. This review offers an in-depth examination of the interplay between epilepsy, mitochondrial function, and aging. Many factors might account for the correlation between epilepsy and aging.
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