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SNIPR alert! Making T cells more precise killers.
Sci Immunol
January 2025
Department of Immunology and Microbiology, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
A cell engineering approach demonstrates that precise regulation of cell signaling can be achieved using both endogenous and synthetic ligands.
View Article and Find Full Text PDF[Meningitis Due to Haemophilus influenzae Serotype A and Adenovirus: A Rare Case of Co-Infection in a Six-Month-Old Infant].
Acta Med Port
January 2025
Serviço de Pediatra e Neonatologia. Unidade Local de Saúde da Póvoa de Varzim. Vila do Conde. Póvoa de Varzim. Portugal.
Haemophilus influenzae serotype A is a rare cause of meningitis and invasive disease in pediatric patients. A six-month-old infant presented to the emergency room with fever, cough and nasal drip. On admission, the infant was alert and hemodynamically stable but progressively became more lethargic with bulging of the fontanelle.
View Article and Find Full Text PDF[Decolonization of autologous blood with cefuroxime during hardware reinfusion in neurosurgical patients].
Zh Vopr Neirokhir Im N N Burdenko
December 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Article Synopsis
- Autologous blood obtained during surgical hardware reinfusion is often contaminated with bacteria, predominantly from skin microflora, in up to 90% of cases, posing a risk for infection.
- Adding cefuroxime to the blood collection process was found to eliminate bacterial growth in 100% of instances when administered initially.
- Despite various decontamination methods, including washing and leukocyte filtration, some bacterial contamination remained, though the combination of these techniques with cefuroxime significantly reduced the risk of bacterial presence in processed blood samples.
What happens to reporting when Bandemia becomes a critical alert?
Am J Emerg Med
January 2025
Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6(th) Floor, Suite 200, Baltimore, MD 21201, United States of America. Electronic address:
Article Synopsis
- Band neutrophil count over 10% (bandemia) in emergency department patients is linked to severe infections.
- A critical alert system for bandemia was put in place in January 2023 to improve patient monitoring.
- Following the alert's implementation, the occurrence of bandemia increased by 4.6 times while the basic characteristics of the patients remained the same.
P-stalk ribosomes act as master regulators of cytokine-mediated processes.
Cell
November 2024
Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address:
Inflammatory cytokines are pivotal to immune responses. Upon cytokine exposure, cells enter an "alert state" that enhances their visibility to the immune system. Here, we identified an alert-state subpopulation of ribosomes defined by the presence of the P-stalk.
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