CCR5-∆32 is deleterious in the homozygous state in humans. | LitMetric

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CCR5-∆32 is deleterious in the homozygous state in humans. | LitMetric

CCR5-∆32 is deleterious in the homozygous state in humans.

Xinzhu Wei Rasmus Nielsen

Nat Med

Department of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA.

Published: June 2019

We use the genotyping and death register information of 409,693 individuals of British ancestry to investigate fitness effects of the CCR5-∆32 mutation. We estimate a 21% increase in the all-cause mortality rate in individuals who are homozygous for the ∆32 allele. A deleterious effect of the ∆32/∆32 mutation is also independently supported by a significant deviation from the Hardy-Weinberg equilibrium (HWE) due to a deficiency of ∆32/∆32 individuals at the time of recruitment.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613792	PMC
http://dx.doi.org/10.1038/s41591-019-0459-6	DOI Listing

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