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Pathophysiology and clinical outcomes of pancytopenia in disseminated histoplasmosis: a scoping review.
Infection
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Article Synopsis
- The study explores the relationship between pancytopenia (a decrease in blood cells) and disseminated histoplasmosis, noting that this connection is rarely documented in existing literature.
- The authors reviewed 72 cases worldwide, primarily from the Americas, finding that many patients had underlying conditions, such as HIV and haemophagocytic lymphohistiocytosis.
- Recovery rates were relatively high at 73.6%, but significant mortality was attributed to diagnostic delays and complications, indicating that early recognition of pancytopenia may be crucial for better patient outcomes.
Pulmonary Embolism Masquerading as Acute Abdominal Pain: A Rare and Challenging Diagnosis.
Cureus
November 2024
Radiology, Second Health Cluster, Jeddah, SAU.
Pulmonary embolism (PE) is a potentially fatal condition with variable clinical presentations, ranging from classic respiratory symptoms to rare atypical manifestations. This report describes a 47-year-old woman who presented with acute, severe right upper quadrant abdominal pain, nausea, and vomiting without respiratory complaints. Initial investigations, including abdominal ultrasound and contrast-enhanced CT of the abdomen, revealed no intra-abdominal abnormalities.
View Article and Find Full Text PDFAngiosarcoma associated with Kasabach-Merritt syndrome presenting with typical signs and symptoms of pulmonary tuberculosis: a case report.
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December 2024
Shifa International Hospital/Shifa Tameer e Millat University, Islamabad, Pakistan.
Background: Angiosarcoma is a rapidly proliferating vascular tumor that originates in endothelial cells of vessels. Rarely, it can be associated with consumptive coagulopathy due to disseminated intravascular coagulation eventually leading to thrombocytopenia and microangiopathic hemolytic anemia. This specific manifestation is termed Kasabach-Merritt syndrome.
View Article and Find Full Text PDFA Fatal Outcome of Ludwig's Angina and Necrotizing Fasciitis Following Traditional Tooth Extraction.
Int Med Case Rep J
December 2024
Department of Oral and Maxillofacial Surgery, Kampala International University-Teaching Hospital, Bushenyi, Uganda.
Ludwig's angina is a potentially fatal condition characterized by a rapid onset of cellulitis that bilaterally involves the submandibular, sublingual, and submental spaces. This report describes the case of a 29-year-old female who presented to us with Ludwig's angina following a tooth extraction performed by a traditional healer in Southwestern Uganda. The patient stayed home for over a week before she could seek formal treatment, and this delay led to severe infection and necrotizing fasciitis with extensive tissue necrosis.
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